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Prusiner and others succeeded in isolating prions associated with the sheep disease ‘scrapie’ in the early 1980’s, and since that time a number of other animal and human diseases have been found to have prions as causative agents. Most notable are the spongiform encephalopathies Creutzfeldt-Jakob and kuru, found in humans, BSE (Mad Cow Disease) in cattle, and TSE (Chronic Wasting Disease) in deer and other animals.The ‘discovery’, or rather proof of existence, of prions made a new line of inquiry available to our researchers, who immediately adapted the techniques used by Prusiner and others to attempt to recover prions from a group of volunteers of our kind. These early attempts failed, for the most part, except when samples were taken from the volunteers’ salivary glands. Further clinical studies, where human volunteers, mostly comprised of close family members of existing lycanthropes, were given subcutaneous injections of various body fluids from the lycanthrope volunteers,. It was still new to Macro – to sit with the King, the Queens, and the ministers in the seats reserved for the ruling class of Tanitsar. As Vice-regent of Tanitsar, he ranked just behind the five Royal Ministers, normally ahead even of the Duke of Beyreth, and the Steward of Tabar. However, since the Duke was also the High Constable of Tanitsar, meaning the supreme commander of all armed forces, Macro found himself sitting in the third pew, between the Duke and his family and the Steward whom he knew well from the campaign against the pirates.Before them on the dais stood the ornate sarcophagus of Queen Ada. She had finally succumbed to the wasting illness a week ago, and Tanitsar was in a state of mourning. The King seemed deep in thought but composed. Macro knew from his mother that Ada had been his least favourite wife. She had chafed under her childless state, and had sometimes vented her frustration on her sister-wives and even the King himself. Most of all, especially in their.
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